Human CCL8 Protein
Catalog No: CCL8-HP001
- Species
- Human
- Expression System
- E.coli
Product overview
Recombinant Human CCL8 Protein is expressed in E. coli without tag. It contains amino acid residues Gln24-Pro99 (UniProt accession: P80075).
Product Details
- Molecular Aliases
- HC14; MCP-2; MCP2; SCYA10; SCYA8
- Protein Length
- Gln24-Pro99
- Expression System
- E.coli
- Theoretical Molecular Weight
- The protein has a predicted MW of 8.91 kDa. The protein migrates to 12-14 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Human CCL8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
C-C motif Chemokine ligand 8 (CCL8) has been found in diseases' pathogenesis. Exogenous CCL8 enhanced the proliferative and migration potential of LE cells and their motility in the environment with its stable concentration.of all the examined factors, chemokine CCL8 participates in the establishment of a proper environment for embryo implantation.
References
- Dai S, Zhang J, Xu Z. Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells. Biosci Biotechnol Biochem. 2020 Aug;84(8):1585-1593. doi: 10.1080/09168451.2020.1762160. Epub 2020 May 20. PMID: 32432500.
- Złotkowska A, Andronowska A. Chemokines as the modulators of endometrial epithelial cells remodelling. Sci Rep. 2019 Sep 10;9(1):12968. doi: 10.1038/s41598-019-49502-5. Erratum in: Sci Rep. 2019 Oct 3;9(1):14467. PMID: 31506569; PMCID: PMC6736846.
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