Immune Checkpoint Proteins
Checkpoint proteins for antibody discovery and assay development.
Explore ProductsOverview
Immune checkpoint proteins regulate activating and inhibitory signals between immune cells and tumor cells. PROVETOP provides research-use proteins for receptor–ligand studies, antibody discovery and assay development. Compare target, species, expression system and tag to identify an appropriate product format.
Priority checkpoint targets
Multiple tags and formats
Product-specific QC evidence
Immune Checkpoint Protein Products
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Performance
CD47 binding activity tested by SPR
Human CD47 Protein (CD47-HP001) binds Human SIRPα–hFc in a Biacore T200 assay.
Reported affinity constant: 18.9 nM
PD-L1 binding activity tested by ELISA
Human PD-L1 Protein (PDL1-HP008) was evaluated for binding to anti-PD-L1 antibody–hFc.
Reported EC50: 6.1 ng/mL
CD47 homogeneity by SEC-HPLC
Representative SEC-HPLC evidence for Human CD47 Protein (CD47-HP001).
Reported purity: >90%
PD-L1 homogeneity by SEC-HPLC
Representative SEC-HPLC evidence for Human PD-L1 Protein (PDL1-HP008).
Reported purity: >95%
