Non-biotinylated Human CXCL4 Protein
Catalog No: CXCL4-HP001
- Species
- Human
- Expression System
- E.coli
- Tag
- His, Avi
Product overview
Recombinant Human CXCL4 Protein is expressed in E. coli with a His tag and Avi tag at the N-terminus. It contains amino acid residues Glu32-Ser101 (accession: NP_002610.1).
Product Details
- Molecular Aliases
- PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298; PF4
- Protein Length
- Glu32-Ser101
- Expression System
- E.coli
- Theoretical Molecular Weight
- The protein has a predicted MW of 10.68 kDa same as Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in 4mM HCl. Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in 4mM HCL. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Human CXCL4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes.
References
- Ruytinx P, Proost P, Struyf S. CXCL4 and CXCL4L1 in cancer. Cytokine. 2018 Sep;109:65-71. doi: 10.1016/j.cyto.2018.02.022. PMID: 29903575.
Have questions about this product?
Our technical team can help with product selection, application questions and order support.