Mouse CXCL4 Protein
Catalog No: CXCL4-MF001
- Species
- Mouse
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Mouse CXCL4 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Val30-Ser105 (UniProt accession: Q9Z126).
Product Details
- Molecular Aliases
- PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298; PF4
- Protein Length
- Val30-Ser105
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 35 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Mouse CXCL4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse CXCL4 is greater than 90% as determined by SEC-HPLC.
Background
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes.
References
- Ruytinx P, Proost P, Struyf S. CXCL4 and CXCL4L1 in cancer. Cytokine. 2018 Sep;109:65-71. doi: 10.1016/j.cyto.2018.02.022. PMID: 29903575.
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