Human CCL20 Protein
Catalog No: CCL20-HP001
- Species
- Human
- Expression System
- E.coli
- Tag
- His
Product overview
Recombinant Human CCL20 Protein is expressed in E. coli with a His tag at the N-terminus. It contains amino acid residues Ala27-Met96 (UniProt accession: P78556-1).
Product Details
- Molecular Aliases
- C-C motif chemokine 20; MIP-3-alpha; LARC; MIP3A; SCYA20; CKb4; Exodus; MIP-3a; ST38; exodus-1; MIP3 alpha; MIP3-alpha
- Protein Length
- Ala27-Met96
- Expression System
- E.coli
- Theoretical Molecular Weight
- The protein has a predicted MW of 9.3 kDa. The protein migrates to 12-14 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Human CCL20 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
Recent evidence suggests that CC chemokine ligand 20 (CCL20) is upregulated after subarachnoid hemorrhage (SAH). CCL20 is upregulated in an SAH mouse model and in cultured primary microglia and neurons. CCL20-neutralizing antibody alleviated SAH-induced neurological deficits, decreased brain water content and neuronal apoptosis, and repressed microglial activation.
References
- Liao LS, Zhang MW, Gu YJ, Sun XC. Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice. Aging (Albany NY). 2020 Jun 21;12(14):14849-14862. doi: 10.18632/aging.103548. Epub 2020 Jun 21. PMID: 32575072; PMCID: PMC7425437.
Have questions about this product?
Our technical team can help with product selection, application questions and order support.