Mouse CXCL16 Protein
Catalog No: CXCL16-MF001
- Species
- Mouse
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Mouse CXCL16 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Asn27-Trp201 (UniProt accession: Q8BSU2).
Product Details
- Molecular Aliases
- SR-PSOX; CXCLG16; SRPSOX; CXCL16; SCYB16
- Protein Length
- Asn27-Trp201
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 45.9 kDa. Due to glycosylation, the protein migrates to 68-70 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Mouse CXCL16 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse CXCL16 is greater than 90% as determined by SEC-HPLC.
Background
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis.
References
- Izquierdo MC, Martin-Cleary C, Fernandez-Fernandez B, Elewa U, Sanchez-Niño MD, Carrero JJ, Ortiz A. CXCL16 in kidney and cardiovascular injury. Cytokine Growth Factor Rev. 2014 Jun;25(3):317-25. doi: 10.1016/j.cytogfr.2014.04.002. Epub 2014 May 2. PMID: 24861945.
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