Human TM4SF1 Nanodisc Protein
Catalog No: TM4SF1-HP002
- Species
- Human
- Expression System
- HEK293
- Tag
- His
Product overview
Human TM4SF1 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human TM4SF1 Nanodisc is expressed from HEK293 with His tag at the N-terminus (FITC-equivalent protein is fused on cytoplasmic part). It contains Met1-Cys202 (accession: P30408).
Product Details
- Molecular Aliases
- M3S1; TAAL6; H-L6; L6
- Protein Length
- Met1-Cys202
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Transmembrane-4-L-six-family-1(TM4SF1), a four-transmembrane L6 family member, is highly expressed in various pancreatic cancer cell lines and promotes cancer cells metastasis. It is upregulated in several epithelial cancers and is closely associated with poor prognosis.
References
- Yang JC, Zhang Y, He SJ, Li MM, Cai XL, Wang H, Xu LM, Cao J. TM4SF1 Promotes Metastasis of Pancreatic Cancer via Regulating the Expression of DDR1. Sci Rep. 2017 Apr 3;7:45895. doi: 10.1038/srep45895. PMID: 28368050; PMCID: PMC5377454.
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