Human CXCL9 Protein
Catalog No: CXCL9-HF001
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Human CXCL9 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the N-terminus. It contains amino acid residues Thr23-Thr125 (UniProt accession: Q07325).
Product Details
- Molecular Aliases
- C-X-C motif chemokine 9; MIG; CMK; SCYB9; Crg-10; Humig; Crg10
- Protein Length
- Thr23-Thr125
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 37.67 kDa. Due to glycosylation, the protein migrates to 42-52 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
- Endotoxin
- Less than 0.1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Human CXCL9 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CXCL9 is greater than 90% as determined by SEC-HPLC.
Background
Chemokine CXCL9 is a member of the CXC family and has an important role in the chemotaxis of immune cells. It is secreted by various cell types including immune cells (T lymphocytes, NK cells 3, dendritic cells 4, macrophages 5, eosinophils 6, etc.), and non-immune cells (hepatic stellate cells 7, preadipocytes, thyrocytes 8, endothelial cell, tumor cells, and fibroblasts 9, etc). CXCL9 has a versatile and controversial role in tumors, and accumulating evidence suggests that CXCL9 is closely associated with the prognosis of tumor patients.
References
- Ding Q, Lu P, Xia Y, Ding S, Fan Y, Li X, Han P, Liu J, Tian D, Liu M. CXCL9: evidence and contradictions for its role in tumor progression. Cancer Med. 2016 Nov;5(11):3246-3259. doi: 10.1002/cam4.934. Epub 2016 Oct 10. PMID: 27726306; PMCID: PMC5119981.
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