Human Claudin 4 Nanodisc Protein
Catalog No: CLDN4-HP002
- Species
- Human
- Expression System
- HEK293
- Tag
- His
Product overview
Human Claudin 4 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human Claudin 4 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val209 (accession: O14493).
Product Details
- Molecular Aliases
- Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
- Protein Length
- Met1-Val209
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
References
- Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy. Int J Mol Sci. 2023 Mar 13;24(6):5494. doi: 10.3390/ijms24065494. PMID: 36982569; PMCID: PMC10051602.
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