Human Claudin 4 VLP Protein
Catalog No: CLDN4-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human Claudin 4 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human Claudin 4 VLP is expressed from HEK293. It contains Met1-Val209 (It may have cross reaction with anti-His antibody) (accession: O14493).
Product Details
- Molecular Aliases
- Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
- Protein Length
- Met1-Val209
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 23.31 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
References
- Fujiwara-Tani R, Mori S, Ogata R, Sasaki R, Ikemoto A, Kishi S, Kondoh M, Kuniyasu H. Claudin-4: A New Molecular Target for Epithelial Cancer Therapy. Int J Mol Sci. 2023 Mar 13;24(6):5494. doi: 10.3390/ijms24065494. PMID: 36982569; PMCID: PMC10051602.
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