Human CDCP1 (338-667) Protein
Catalog No: CDCP1-HF002
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Human CDCP1 (338-667) Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the N-terminus. It contains amino acid residues Gln338-Thr667 (UniProt accession: Q9H5V8-1).
Product Details
- Molecular Aliases
- CDCP1; CD318; SIMA135; TRASK; UNQ2486; PRO5773
- Protein Length
- Gln338-Thr667
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 64.2 kDa. Due to glycosylation, the protein migrates to 75-90 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 0.1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Human CDCP1 (338-667) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human CDCP1 (338-667) is greater than 95% as determined by SEC-HPLC.
Background
Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
References
- Wright HJ, Hou J, Xu B, Cortez M, Potma EO, Tromberg BJ, Razorenova OV. CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6556-E6565. doi: 10.1073/pnas.1703791114. Epub 2017 Jul
- PMID: 28739932; PMCID: PMC5559020.
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