Human CCR8 VLP Protein
Catalog No: CCR8-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human CCR8 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains the indicated native protein sequence.
Product Details
- Molecular Aliases
- CCR-8; CMKBRL2; CKR-L1; GPR-CY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CY6; TER-1; CDw198
- Protein Length
- Met1-Leu355
- Expression System
- HEK293
- Theoretical Molecular Weight
- 44.06 kDa
- Purity
- >95% (HPLC)
- Endotoxin
- <1 EU/μg (LAL assay)
- Buffer / Formulation
- 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4. A water-soluble adjuvant is recommended for immunization applications.
- State
- Liquid
- Storage Conditions
- Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
CCR8 (CD198) is a CC chemokine receptor expressed on cell populations including Th2 cells and eosinophils. It has been studied in allergic inflammation, monocyte chemotaxis and thymic cell biology, and can act as an alternative HIV-1 coreceptor with CD4.
References
- Berenguer J, Lagerweij T, Zhao XW, et al. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018;7(1):1446660.
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