Biotinylated Mouse Siglec-15/CD33L3 Protein (Primary Amine Labeling)
Catalog No: CD33L3-MB001
- Species
- Mouse
- Expression System
- HEK293
- Tag
- His
Product overview
Recombinant Biotinylated Mouse Siglec-15/CD33L3 Protein (Primary Amine Labeling) is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Arg24-Thr262 (accession: A7E1W8-1).
Product Details
- Molecular Aliases
- CD33 molecule-like 3; CD33L3; HsT1361; Siglec15; CD33 antigen-like 3; SIGLEC-15
- Protein Length
- Arg24-Thr262
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 26.7 kDa. Due to glycosylation, the protein migrates to 35-43 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in 20mM PB, 0.5M NaCl, 0.1M L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Biotinylated Mouse Siglec-15/CD33L3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
References
- Jun Wang,et al. Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nature Medicine
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