Biotinylated Human STEAP1 VLP
Catalog No: STEAP1-HB002
- Species
- Human
- Expression System
- HEK293
- Tag
- Biotin, His
- Activity
- Activity verified
Product overview
Recombinant Biotinylated Human STEAP1 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Leu339 (It may have cross reaction with anti-His antibody) (UniProt accession: Q9UHE8).
Product Details
- Molecular Aliases
- PRSS24; STEAP; PRSS24, STEAP 1;PRSS24, STEAP1
- Protein Length
- Met1-Leu339
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 43.06 kDa.
- Purity
- > 95% as determined by HPLC
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
The purity of Biotinylated Human STEAP1 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human STEAP1 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Vandortuzumab, hFc Tag with the EC50 of 91.2ng/ml determined by ELISA. (QC Test)
Background
Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III).
References
- Oosterheert W, Gros P. Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1). J Biol Chem. 2020 Jul 10;295(28):9502-9512. doi: 10.1074/jbc.RA120.013690. Epub 2020 May 14. PMID: 32409586; PMCID: PMC7363144.
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