Biotinylated Human STEAP1 VLP Protein
Catalog No: STEAP1-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- Biotin
Product overview
Biotinylated Human STEAP1 VLP Protein is a full-length multi-pass membrane protein presented in a VLP format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human STEAP1 VLP is expressed from HEK293. It contains Met1-Leu339 (It may have cross reaction with anti-His antibody) (accession: Q9UHE8).
Product Details
- Molecular Aliases
- PRSS24; STEAP; PRSS24 / STEAP 1
- Protein Length
- Met1-Leu339
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 43.06 kDa.
- Purity
- > 95% as determined by HPLC 制剂（Formulation） Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4). 存储（Storage） Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. 阴性对照 （Recommended Negative Control） CON-HM00VB 表达区间及表达系统（Source） Recombinant Biotinylated Human STEAP1 VLP is expressed from HEK293. It contains Met1-Leu339 (It may have cross reaction with anti-His antibody) (accession: Q9UHE8). 分子量大小（Molecular Weight） The protein has a predicted MW of 43.06 kDa. 纯度（Purity） > 95% as determined by HPLC
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Six-transmembrane epithelial antigen of the prostate 1 (STEAP1) is an integral membrane protein that is highly up-regulated on the cell surface of several human cancers, making it a promising therapeutic target to manage these diseases. It shares sequence homology with three enzymes (STEAP2-STEAP4) that catalyze the NADPH-dependent reduction of iron(III).
References
- Oosterheert W, Gros P. Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1). J Biol Chem. 2020 Jul 10;295(28):9502-9512. doi: 10.1074/jbc.RA120.013690. Epub 2020 May 14. PMID: 32409586; PMCID: PMC7363144.
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