Biotinylated Human CD20/MS4A1 VLP Protein
Catalog No: CD20-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- Biotin
Product overview
Biotinylated Human CD20/MS4A1 VLP Protein is a full-length multi-pass membrane protein presented in a VLP format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CD20/MS4A1 VLP is expressed from HEK293. It contains Met1-Pro297 (It may have cross reaction with anti-His antibody) (accession: P11836-1).
Product Details
- Molecular Aliases
- MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7
- Protein Length
- Met1-Pro297
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 34.3 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R, CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.
References
- (1)Ma D, Mcdevitt M R, Barendswaard E, et al. Radioimmunotherapy for model B cell malignancies using 90Y-labeled anti-CD19 and anti-CD20 monoclonal antibodies[J]. Leukemia, 2002, 16(1):60-66. (2)Jager U, Fridrik M, Zeitlinger M, et al. Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response[J]. Haematologica, 2012, 97(9):1431-1438.
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