Human CD84/SLAMF5 Protein
Catalog No: CD84-HF001
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Human CD84/SLAMF5 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Lys22-Gly225 (UniProt accession: Q9UIB8-1).
Product Details
- Molecular Aliases
- Hly9-beta; CD84; SLAMF5; LY9B; CD84 molecule; DKFZp781E2378;Hly9-β;Hly9-b; Hly9b
- Protein Length
- Lys22-Gly225
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 48.73 kDa. Due to glycosylation, the protein migrates to 65-85 kDa based on Bis-Tris PAGE result.
- Purity
- > 80% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 0.1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Human CD84 on Bis-Tris PAGE under reduced condition. The purity is greater than 80%.
Background
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
References
- Binsky-Ehrenreich I, Marom A, Sobotta MC, Shvidel L, Berrebi A, Hazan-Halevy I, Kay S, Aloshin A, Sagi I, Goldenberg DM, Leng L, Bucala R, Herishanu Y, Haran M, Shachar I. CD84 is a survival receptor for CLL cells. Oncogene. 2014 Feb 20;33(8):1006-16. doi: 10.1038/onc.2013.31. Epub 2013 Feb
- PMID: 23435417; PMCID: PMC3796123.
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