Mouse ALK Protein
Catalog No: ALK-MF001
- Species
- Mouse
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Mouse ALK Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Ser19-Cys692 (UniProt accession: P97793).
Product Details
- Molecular Aliases
- ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246;
- Protein Length
- Ser19-Cys692
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 101.11 kDa. Due to glycosylation, the protein migrates to 115-125 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 10% Glycerol (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Mouse ALK on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ALK is greater than 90% as determined by SEC-HPLC.
Background
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises.
References
- Wang L, Lui VWY. Emerging Roles of ALK in Immunity and Insights for Immunotherapy. Cancers (Basel). 2020 Feb 12;12(2):426. doi: 10.3390/cancers12020426. PMID: 32059449; PMCID: PMC7072244.
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