FITC-Labeled Human NKG2D/CD314 Protein
Catalog No: CD314-HF002
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1), Flag
Product overview
Recombinant FITC-Labeled Human NKG2D/CD314 Protein is expressed in HEK293 cells with an hFc (IgG1) tag and Flag tag at the N-terminus. It contains amino acid residues Phe78-Val216 (UniProt accession: P26718).
Product Details
- Molecular Aliases
- CD314; D12S2489E; KLR; NKG2-D; NKG2D
- Protein Length
- Phe78-Val216
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 43.4 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
FITC-Labeled Human NKG2D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of FITC-Labeled Human NKG2D is greater than 95% as determined by SEC-HPLC.
Background
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells.
References
- Spear P, Barber A, Rynda-Apple A, et al. NKG2D CAR T-cell therapy inhibits the growth of NKG2D ligand heterogeneous tumors[J]. Immunology and Cell Biology, 2013, 91(6):435-440.
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