Human EDNRA VLP Protein
Catalog No: EDNRA-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human EDNRA VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human EDNRA VLP is expressed from HEK293. It contains Met1-Asn427 (It may have cross reaction with anti-His antibody) (accession: P25101-1).
Product Details
- Molecular Aliases
- EDNRA; ET-A; ETA-R; hET-AR; ETA; ETRA
- Protein Length
- Met1-Asn427
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 150mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
The endothelin-A receptor (Ednra) is involved in several physiological, pathological, and developmental pathways. Known for its function in vasoconstriction after being activated by endothelin-1, Ednra also controls cephalic neural crest cell development and appears to play a role in several pathologies, including cancer and periodontitis.
References
- Zhang Y, Knutsen GR, Brown MD, Ruest LB. Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2. Mol Endocrinol. 2013 Jun;27(6):892-908. doi: 10.1210/me.2012-1334. Epub 2013 Apr 16. PMID: 23592430; PMCID: PMC3656236.
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