Biotinylated Human EDNRA Nanodisc
Catalog No: EDNRA-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His
- Activity
- Activity verified
Product overview
Recombinant Biotinylated Human EDNRA Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Asn427 (UniProt accession: P25101-1).
Product Details
- Molecular Aliases
- EDNRA; ET-A; ETA-R; hET-AR; ETA; ETRA
- Protein Length
- Met1-Asn427
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 61.70 kDa.
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Immobilized Biotinylated Human EDNRA Nanodisc, His Tag 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-EDNRA Antibody, hFc Tag with the EC50 of 0.17μg/ml determined by ELISA. (QC Test)
Background
The endothelin-A receptor (Ednra) is involved in several physiological, pathological, and developmental pathways. Known for its function in vasoconstriction after being activated by endothelin-1, Ednra also controls cephalic neural crest cell development and appears to play a role in several pathologies, including cancer and periodontitis.
References
- Zhang Y, Knutsen GR, Brown MD, Ruest LB. Control of endothelin-a receptor expression by progesterone is enhanced by synergy with Gata2. Mol Endocrinol. 2013 Jun;27(6):892-908. doi: 10.1210/me.2012-1334. Epub 2013 Apr 16. PMID: 23592430; PMCID: PMC3656236.
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