Human CD133 VLP Protein
Catalog No: CD133-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human CD133 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human CD133 VLP is expressed from HEK293. It contains Met1-His865 (It may have cross reaction with anti-His antibody) (accession: O43490-1).
Product Details
- Molecular Aliases
- PROM1; PROML1; MSTP061; Prominin-1; AC133
- Protein Length
- Met1-His865
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 150mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Prominin-1 (PROM1), also known as CD133, is expressed in hepatic progenitor cells (HPCs) and cholangiocytes of the fibrotic liver. It is a cell surface biomarker that allows the identification of stem and cancer stem cells from different organs. It is also expressed in several differentiated epithelial and non-epithelial cells.
References
- (1) Thamm K, Šimaitė D, Karbanová J, Bermúdez V, Reichert D, Morgenstern A, Bornhäuser M, Huttner WB, Wilsch-Bräuninger M, Corbeil D. Prominin-1 (CD133) modulates the architecture and dynamics of microvilli. Traffic. 2019 Jan;20(1):39-60. doi: 10.1111/tra.12618. Epub 2018 Nov 14. PMID: 30328220.(2) Lee H, Yu DM, Bahn MS, Kwon YJ, Um MJ, Yoon SY, Kim KT, Lee MW, Jo SJ, Lee S, Koo SH, Jung KH, Lee JS, Ko YG. Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7. Exp Mol Med. 2022 Aug;54(8):1277-1289. doi: 10.1038/s12276-022-00831-y. Epub 2022 Aug 29. PMID: 36038590; PMCID: PMC9440255.
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