Human Proteinase-activated receptor 1/PAR-1 VLP Protein
Catalog No: PAR1-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human Proteinase-activated receptor 1/PAR-1 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human Proteinase-activated receptor 1/PAR-1 VLP is expressed from HEK293. It contains Met1-Thr425 (It may have cross reaction with anti-His antibody) (accession: P25116).
Product Details
- Molecular Aliases
- Proteinase-activated receptor 1; PAR-1; Coagulation factor II receptor; Thrombin receptor; F2R; CF2R; PAR1; TR
- Protein Length
- Met1-Thr425
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 48.79 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 150mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Proteinase activated receptors (PAR 1-4) are membrane receptors with a unique way of activation by proteinases like thrombin, trypsin and matrix metalloproteinases which lead to a specific cellular response. PAR-1 was present in adenocarcinomas, melanomas, osteosarcomas, glioblastomas, meningiomas, leukaemias and squamous cell carcinomas. PAR-1 is widely expressed in human tumors suggesting an important role in tumorigenesis and providing potential targets for therapy.
References
- Elste AP, Petersen I. Expression of proteinase-activated receptor 1-4 (PAR 1-4) in human cancer. J Mol Histol. 2010 Apr;41(2-3):89-99. doi: 10.1007/s10735-010-9274-6. Epub 2010 Jun 20. PMID: 20563836.
Have questions about this product?
Our technical team can help with product selection, application questions and order support.