Human N Cadherin Protein
Catalog No: NCADHERIN-HF001
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Human N Cadherin Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Asp160-Ala724 (accession: NP_001783.2).
Product Details
- Molecular Aliases
- CDH2; N-cadherin; Neural cadherin; CD325; CDHN; CDw325; NCAD;
- Protein Length
- Asp160-Ala724
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 88.56 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result.
- Purity
- > 90% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Human N Cadherin on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
Background
Neural (N)-cadherin is a calcium-dependent single-chain transmembrane glycoprotein that mediates homotypic and heterotypic cell-cell adhesion. As an important member of the cadherin family, N-cadherin plays an important role in the developmental and functional regulation of the nervous system, brain, heart, skeletal muscles, blood vessels and hematopoietic microenvironment.
References
- Cao ZQ, Wang Z, Leng P. Aberrant N-cadherin expression in cancer. Biomed Pharmacother. 2019 Oct;118:109320. doi: 10.1016/j.biopha.2019.109320. Epub 2019 Aug 12. PMID: 31545265.
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