FITC-Labeled Human Siglec-2/CD22 Protein
Catalog No: CD22-HF002
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant FITC-Labeled Human Siglec-2/CD22 Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Asp20-Arg687 (UniProt accession: P20273-1).
Product Details
- Molecular Aliases
- CD22 molecule; CD22; Siglec-2; B-cell receptor CD22; BL-CAM; SIGLEC2; SIGLEC2FLJ22814
- Protein Length
- Asp20-Arg687
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 101.9 kDa. Due to glycosylation, the protein migrates to 130-140 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
FITC-Labeled Human Siglec-2/CD22 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
CD22, or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice.
References
- Kato J, Robert T. O'Donnell, Abuhay M, et al. Efficacy and toxicity of a CD22-targeted antibody-saporin conjugate in a xenograft model of non-Hodgkin's lymphoma[J]. OncoImmunology, 2012, 1(9):7.
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