Biotinylated Human SEZ6L2 Protein
Catalog No: SEZ6L2-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His, Avi
Product overview
Recombinant Biotinylated Human SEZ6L2 Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Leu28-Asn844 (UniProt accession: Q6UXD5-1).
Product Details
- Molecular Aliases
- BSRP-A; PSK-1; SEZ6L2; UNQ1903/PRO4349; PSK1
- Protein Length
- Leu28-Asn844
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 90.33 kDa. Due to glycosylation, the protein migrates to 110-170 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Biotinylated Human SEZ6L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Background
Seizure-related 6 homolog (mouse)-like 2 (SEZ6L2) was shown to be involved in transcription of a type 1 transmembrane protein for regulating cell fate. SEZ6L2 was significantly up-regulated in tumour tissues of patients with CRC compared with adjacent normal tissues. Up-regulation of SEZ6L2 was correlated with a poor prognosis in patients with CRC. Furthermore, SEZ6L2 expression was inversely correlated with the expression of cytochrome C in malignant tissues in patients with CRC.
References
- An N, Zhao Y, Lan H, Zhang M, Yin Y, Yi C. SEZ6L2 knockdown impairs tumour growth by promoting caspase-dependent apoptosis in colorectal cancer. J Cell Mol Med. 2020 Apr;24(7):4223-4232. doi: 10.1111/jcmm.15082. Epub 2020 Feb 27. PMID: 32105413; PMCID: PMC7171412.
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