Biotinylated Human IGF2R Protein
Catalog No: IGF2R-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His, Avi
Product overview
Recombinant Biotinylated Human IGF2R Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Glu47-Met1508 (UniProt accession: P11717).
Product Details
- Molecular Aliases
- CI-MPR; M6PR; MPR 300; IGF-II receptor; M6P/IGF2R; CD222; MPRI;MPR300
- Protein Length
- Glu47-Met1508
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 164.90 kDa. Due to glycosylation, the protein migrates to 180-220 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Biotinylated Human IGF2R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human IGF2R is greater than 95% as determined by SEC-HPLC.
Background
The cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) is a multifunctional receptor. It is involved in a variety of cellular processes which become dysregulated in cancer.
References
- Martin-Kleiner I, Gall Troselj K. Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis. Cancer Lett. 2010 Mar 1;289(1):11-22. doi: 10.1016/j.canlet.2009.06.036. Epub 2009 Jul 30. PMID: 19646808.
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