Biotinylated Human GPRC5D VLP Protein
Catalog No: GPRC5D-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- Biotin
Product overview
Biotinylated Human GPRC5D VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human GPRC5D VLP is expressed from HEK293. It contains Met1-Val345 (It may have cross reaction with anti-His antibody) (accession: Q9NZD1-1).
Product Details
- Molecular Aliases
- GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor
- Protein Length
- Met1-Val345
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 39.6 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
G protein–coupled receptor, family C, group 5, member D (GPRC5D) is an orphan receptor that is primarily expressed in plasma cells and hard keratinized tissues, with low expression in normal human tissues. GPRC5D expression is enriched in malignant plasma cells and is associated with markers of high-risk myeloma.
References
- Chari A, Minnema MC, Berdeja JG, Oriol A, van de Donk NWCJ, Rodríguez-Otero P, Askari E, Mateos MV, Costa LJ, Caers J, Verona R, Girgis S, Yang S, Goldsmith RB, Yao X, Pillarisetti K, Hilder BW, Russell J, Goldberg JD, Krishnan A. Talquetamab, a T-Cell-Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma. N Engl J Med. 2022 Dec 15;387(24):2232-2244. doi: 10.1056/NEJMoa2204591. Epub 2022 Dec 10. PMID: 36507686.
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