Biotinylated Human CX3CR1 Nanodisc Protein
Catalog No: CX3CR1-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His
Product overview
Biotinylated Human CX3CR1 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CX3CR1 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Leu355 (accession: P49238-1).
Product Details
- Molecular Aliases
- CX3C chemokine receptor 1; C-X3-C CKR-1; CMK-BRL-1; CMK-BRL1; V28; CMKBRL1; GPR13; GPRV28
- Protein Length
- Met1-Leu355
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
CX3CR1, also known as G-protein coupled receptor 13, is a receptor of CX3CL1. It is primarily expressed on monocytes, macrophages, dendritic cells, T cells, and natural killer cells. The binding of CX3CL1 to CX3CR1 induces the activation of heterotrimeric G proteins associated with this receptor. In addition, it triggers the signal pathways of MAPK and AKT, which play essential roles in tumour biology.
References
- Lu X. Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer. Curr Med Chem. 2022;29(41):6228-6246. doi: 10.2174/0929867329666220629140540. PMID: 35770395.
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