Biotinylated Canine TSLP (R127A, R130A) Protein
Catalog No: TSLP-DB001
- Species
- Canine
- Expression System
- HEK293
- Tag
- His, Avi
Product overview
Recombinant Biotinylated Canine TSLP (R127A, R130A) Protein is expressed in HEK293 cells with a His tag and Avi tag at the C-terminus. It contains amino acid residues Tyr28-Ser154(R126A, R129A) (accession: I1VWC7).
Product Details
- Molecular Aliases
- thymic stromal lymphopoietin; TSLP
- Protein Length
- Tyr28-Ser154
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 17.25 kDa. Due to glycosylation, the protein migrates to 18-20 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Biotinylated Canine TSLP (R127A, R130A) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Canine TSLP (R127A, R130A) is greater than 95% as determined by SEC-HPLC.
Background
Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c dendritic cells. Can induce allergic inflammation by directly activating mast cells.
References
- Corren J, Parnes J R, Wang L, et al. Tezepelumab in Adults with Uncontrolled Asthma[J]. New England Journal of Medicine, 2017, 377(10):936-946.
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