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APC-Labeled Human HLA-A*02:01&B2M&CG1 (FLLPTGAEA) Tetramer Protein

Catalog No: HLAA0201-HP014

Species
Human
Expression System
E. coli
Tag
His, Avi

Product overview

Recombinant APC-Labeled Human HLA-A*02:01&B2M&CG1 (FLLPTGAEA) Tetramer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. APC-Labeled Human HLA-A*02:01&B2M&CG1 (FLLPTGAEA) Tetramer is assembled by biotinylated monomer and APC-Labeled streptavidin. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and FLLPTGAEA peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &FLLPTGAEA).

Product Details

Molecular Aliases
CG1 (FLLPTGAEA)
Protein Length
Gly25-Thr305
Expression System
E. coli
Buffer / Formulation
Supplied as 0.22 μm filtered solution in 20mM Tris, 200mM NaCl, 0.2% BSA (pH 8.0).
State
Liquid
Storage Conditions
Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Background

Cathepsin G (CG) is a myeloid azurophil granule protease that is highly expressed by acute myeloid leukemia (AML) blasts and leukemia stem cells. CG1 (FLLPTGAEA) is a human leukocyte antigen-A2-restricted nonameric peptide derived from CG that can act as an immunogenic target in AML.

References

  1. [1] Khan M, Carmona S, Sukhumalchandra P, Roszik J, Philips A, Perakis AA, Kerros C, Zhang M, Qiao N, John LSS, Zope M, Goldberg J, Qazilbash M, Jakher H, Clise-Dwyer K, Qiu Y, Mittendorf EA, Molldrem JJ, Kornblau SM, Alatrash G. Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target. Front Immunol. 2018 Jan 25;8:1975. doi: 10.3389/fimmu.2017.01975. PMID: 29422892; PMCID: PMC5790053.
  2. [2] Shi C, Tian Z, Yan J, Zhang M, Sukhumalchandra P, Chang E, Yang G, You J, Cui M, Shi Q, Kerros C, Philips A, Qiao N, Torikai H, Patchametla S, Sergeeva A, St John L, He H, Wiederschain D, Lee BH, Paulus GLC, Zha D, Molldrem J, Alatrash G. Immunotherapy targeting a leader sequence cathepsin G-derived peptide. Leukemia. 2025 Apr;39(4):888-898. doi: 10.1038/s41375-025-02520-x. Epub 2025 Feb 12. PMID: 39939820; PMCID: PMC11976275.

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