Human ACVR1/Activin RI Protein
Catalog No: ACVR1-HF001
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1)
Product overview
Recombinant Human ACVR1/Activin RI Protein is expressed in HEK293 cells with an hFc (IgG1) tag at the C-terminus. It contains amino acid residues Met21-Glu123 (UniProt accession: Q04771).
Product Details
- Molecular Aliases
- Activin RIA; ACTR-I; ALK-2; ACVR1; SKR1; TSR-I; ACVRLK2; Activin RI; Activin R1; ACVR1A;ALK2
- Protein Length
- Met21-Glu123
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 37.43 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Human ACVR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human ACVR1 is greater than 95% as determined by SEC-HPLC.
Background
Activin A receptor type I (ACVR1), a transmembrane serine/threonine kinase, belongs to the transforming growth factor-β superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans progressive, and its somatic alteration is reported in rare cancer diffuse intrinsic pontine glioma.
References
- Nagar G, Mittal P, Gupta SRR, Pahuja M, Sanger M, Mishra R, Singh A, Singh IK. Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting. Brief Funct Genomics. 2023 Apr 13;22(2):123-142. doi: 10.1093/bfgp/elac026. PMID: 36003055.
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