Biotinylated Human CLEC2D Protein
Catalog No: CLEC2D-HF001
- Species
- Human
- Expression System
- HEK293
- Tag
- an hFc (IgG1), Avi
Product overview
Recombinant Biotinylated Human CLEC2D Protein is expressed in HEK293 cells with an hFc (IgG1) tag and Avi tag at the N-terminus. It contains amino acid residues Arg60-Val191 (UniProt accession: Q9UHP7-1).
Product Details
- Molecular Aliases
- LLT-1; CLAX; LLT1; OCIL; CLEC2D; CLAXLLT-1; OCILmember D;CLAXLLT1
- Protein Length
- Arg60-Val191
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 59.1 kDa. Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Biotinylated Human CLEC2D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human CLEC2D is greater than 95% as determined by SEC-HPLC.
Background
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.
References
- Varaden D, Moodley J, Onyangunga OA, Naicker T. Morphometric image analysis of placental C-type lectin domain family 2, member D (CLEC2D) immuno-expression in HIV associated pre-eclampsia. Eur J Obstet Gynecol Reprod Biol X. 2019 May 8;3:100039. doi: 10.1016/j.eurox.2019.100039. PMID: 31403127; PMCID: PMC6687384.
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