Biotinylated Human STEAP2 VLP
Catalog No: STEAP2-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- Biotin, His
- Activity
- Activity verified
Product overview
Recombinant Biotinylated Human STEAP2 VLP is expressed in HEK293 cells. It contains amino acid residues Met1-Met490 (It may have cross reaction with anti-His antibody) (UniProt accession: Q8NFT2-1).
Product Details
- Molecular Aliases
- PUMPCn; PCANAP1; STAMP1; STEAP 2; STMP; IPCA-1;STEAP2; IPCA1
- Protein Length
- Met1-Met490
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 66.72 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
The purity of Biotinylated Human STEAP2 VLP is greater than 95% as determined by SEC-HPLC.
Immobilized Biotinylated Human STEAP2 VLP at 5μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-STEAP2 Antibody, hFc Tag with the EC50 of 10.9ng/ml determined by ELISA. (QC Test)
Background
STEAP2, also known as the six transmembrane protein of prostate 1 (STAMP1), is located on chromosome 7q21.13, contains 6 exons and 5 introns, and encodes for a 490 aa long protein with an estimated molecular weight of 56.1 kDa. STEAP2 has been suggested to play a role in protein sorting and secretory pathways, as it shuttles to the Golgi organelle and trans-Golgi network. STEAP2 is significantly overexpressed in prostate cancer when compared to normal healthy tissue.
References
- Jones LA, Conway GE, Nguyen-Chi A, Burnell S, Jenkins GJ, Conlan RS, Doak SH. Investigating STEAP2 as a potential therapeutic target for the treatment of aggressive prostate cancer. Cell Mol Biol (Noisy-le-grand). 2023 Apr 30;69(4):179-187. doi: 10.14715/cmb/2023.69.4.28. PMID: 37329528.
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