Biotinylated Human SSTR2 Nanodisc
Catalog No: SSTR2-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His
- Activity
- Activity verified
Product overview
Recombinant Biotinylated Human SSTR2 Nanodisc is expressed in HEK293 cells with a His tag at the C-terminus. It contains amino acid residues Met1-Ile369 (UniProt accession: P30874-1).
Product Details
- Molecular Aliases
- SS-2-R; SS2-R; SS2R; SRIF-1; SRIF1; SRIF 1; Smstr2; SST2; SSTR2
- Protein Length
- Met1-Ile369
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 54.30 kDa.
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 6 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Immobilized Biotinylated Human SSTR2 Nanodisc, His Tag at 2μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml). Dose response curve for Anti-SSTR2 Antibody, hFc Tag with the EC50 of 6.0ng/ml determined by ELISA. (QC Test)
Biotinylated Human SSTR2 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-SSTR2 Antibody, hFc-Avi tag with an affinity constant of 0.23 nM as determined in SPR assay (Biacore S200).
Background
Somatostatin receptor (SSTR) 2, widely expressed in meningioma, is a G-protein-coupled receptor and can be activated by somatostatin or its synthetic analogs. SSTR2 is therefore extensively studied as a marker and target for the diagnosis and treatment of meningioma.
References
- Wu W, Zhou Y, Wang Y, Liu L, Lou J, Deng Y, Zhao P, Shao A. Clinical Significance of Somatostatin Receptor (SSTR) 2 in Meningioma. Front Oncol. 2020 Sep 3;10:1633. doi: 10.3389/fonc.2020.01633. PMID: 33014821; PMCID: PMC7494964.
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