Human Claudin 9 VLP Protein
Catalog No: CLDN9-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human Claudin 9 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human Claudin 9 VLP is expressed from HEK293. It contains Met1-Val217 (It may have cross reaction with anti-His antibody) (accession: O95484).
Product Details
- Molecular Aliases
- CLDN9; Claudin-9; Claudin9;
- Protein Length
- Met1-Val217
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 24.1 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Claudins (CLDNs) are tetraspan proteins with a short cytoplasmic N‑terminus, two extracellular loops and a C‑terminal cytoplasmic domain. They function as a physical barrier or gate of small molecules and as signaling platforms to coordinate diverse cellular behaviors. CLDNs are useful cancer biomarkers, as they are frequently upregulated and are associated with malignant traits of cancers, such as invasion, migration, metastasis and chemoresistance. Claudin‑9 (CLDN9) is barely distributed in normal adult tissues but is ectopically expressed in various cancer types.
References
- Endo Y, Sugimoto K, Kobayashi M, Kobayashi Y, Kojima M, Furukawa S, Soeda S, Watanabe T, Higashi AY, Higashi T, Hashimoto Y, Fujimori K, Chiba H. Claudin‑9 is a novel prognostic biomarker for endometrial cancer. Int J Oncol. 2022 Nov;61(5):135. doi: 10.3892/ijo.2022.5425. Epub 2022 Sep 21. PMID: 36129146; PMCID: PMC9521636.
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