Biotinylated Human TGFBR1 Protein
Catalog No: TGFBR1-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- an mFc (IgG1), Avi
Product overview
Recombinant Biotinylated Human TGFBR1 Protein is expressed in HEK293 cells with an mFc (IgG1) tag and Avi tag at the C-terminus. It contains amino acid residues Leu34-Glu125 (UniProt accession: P36897-1).
Product Details
- Molecular Aliases
- AAT5; ACVRLK4; ALK-5; ALK5; LDS1A; LDS2A; SKR4; tbetaR-I; TGFB1R1; TGF-beta RI; TGFbetaRI; TGFBR1; TGF-bRI; TGFR-1; tβR-I; TGF-β RI; TGFβRI;TGFR1;tbR-I; t beta R-I; TGF-b RI; TGFbRI; TGF beta RI
- Protein Length
- Leu34-Glu125
- Expression System
- HEK293
- Theoretical Molecular Weight
- The protein has a predicted MW of 38.2 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
- State
- Lyophilized
- Storage Conditions
- -20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3 months after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Reconstitution Advice
- Dissolve the lyophilized protein in distilled water. Please refer to the Certificate of Analysis for detailed instructions.
Data Display
Biotinylated Human TGFBR1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human TGFBR1 is greater than 95% as determined by SEC-HPLC.
Background
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells.
References
- Jiang F, Yu Q, Chu Y, Zhu X, Lu W, Liu Q, Wang Q. MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. Int J Oncol. 2019 Jan;54(1):128-138. doi: 10.3892/ijo.2018.4610. Epub 2018 Oct 29. PMID: 30387848; PMCID: PMC6255066.
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