Human MRGPRX2 VLP Protein
Catalog No: MRGPRX2-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human MRGPRX2 VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. Recombinant Human MRGPRX2 VLP is expressed from HEK293. It contains Met1-Val330 (It may have cross reaction with anti-His antibody) (accession: Q96LB1).
Product Details
- Molecular Aliases
- MRGX2
- Protein Length
- Met1-Val330
- Expression System
- HEK293
- Theoretical Molecular Weight
- The target protein has a predicted MW of 40.31 kDa.
- Purity
- > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22μm filtered solution in PBS, 300mM L-arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
As receptor for multiple drugs, MRGPRX2 is crucial to drug-induced hypersensitivity. However, not only drugs, but also endogenous mediators like neuropeptides and host defense peptides activate MRGPRX2, suggesting its broad impact in cutaneous pathophysiology.
References
- Wang Z, Babina M. MRGPRX2 signals its importance in cutaneous mast cell biology: Does MRGPRX2 connect mast cells and atopic dermatitis? Exp Dermatol. 2020 Nov;29(11):1104-1111. doi: 10.1111/exd.14182. Epub 2020 Sep 17. PMID: 32866307.
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