Human CCR2b VLP Protein
Catalog No: CCR2-HP001
- Species
- Human
- Expression System
- HEK293
Product overview
Human CCR2b VLP Protein is a full-length multi-pass membrane protein displayed in a VLP format for antibody discovery, binding assays and method development. The construct is expressed in HEK293 cells and contains the indicated native protein sequence.
Product Details
- Molecular Aliases
- C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2
- Protein Length
- Met1-Leu360
- Expression System
- HEK293
- Theoretical Molecular Weight
- 42.9 kDa
- Purity
- >95% (HPLC)
- Endotoxin
- <1 EU/μg (LAL assay)
- Buffer / Formulation
- 0.22 μm filtered solution in PBS with 300 mM L-arginine, pH 7.4. A water-soluble adjuvant is recommended for immunization applications.
- State
- Liquid
- Storage Conditions
- Store at -80°C for up to 12 months. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
The chemokine receptor CCR2B is an isoform of the receptor for CCL2, a major monocyte chemoattractant involved in inflammatory signaling. Filamin A associates with the CCR2B C-terminal region and contributes to receptor internalization and membrane localization.
References
- Minsaas L, Planagumà J, Madziva M, et al. Filamin A binds to CCR2B and regulates its internalization. PLoS One. 2010;5(8):e12212. doi:10.1371/journal.pone.0012212. PMID: 20808917.
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