Human HLA-A*02:01&B2M&FOXI3 (AAPGAPPAA) Monomer Protein
Catalog No: HLAA0201-HP005
- Species
- Human
- Expression System
- E. coli
- Tag
- His, Avi
Product overview
Recombinant Human HLA-A*02:01&B2M&FOXI3 (AAPGAPPAA) Monomer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and AAPGAPPAA peptide (accession: A0A140T913(HLA-A*02:01) & P61769(B2M) &AAPGAPPAA).
Product Details
- Molecular Aliases
- FOXI3; AAPGAPPAA
- Protein Length
- Gly25-Thr305
- Expression System
- E. coli
- Theoretical Molecular Weight
- The protein has a predicted MW of 35.6 kDa (HLA-A*02:01) and 11.9 kDa (B2M) same as Bis-Tris PAGE result.
- Purity
- > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in 20 mM Tris, 200 mM NaCl (pH 8.0).
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Data Display
Human HLA-A*02:01&B2M&FOXI3 (AAPGAPPAA) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Human HLA-A*02:01&B2M&FOXI3 (AAPGAPPAA) Monomer is greater than 95% as determined by SEC-HPLC.
Background
The gene FOXO3, encoding the transcription factor forkhead box O-3 (FoxO3), is one of only two for which genetic polymorphisms have exhibited consistent associations with longevity in diverse human populations. Diseases associated with FOXI3 include Craniofacial Microsomia 2 and Craniofacial Microsomia.
References
- Morris BJ, Willcox DC, Donlon TA, Willcox BJ. FOXO3: A Major Gene for Human Longevity--A Mini-Review. Gerontology. 2015;61(6):515-25. doi: 10.1159/000375235. Epub 2015 Mar 28. PMID: 25832544; PMCID: PMC5403515.
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