Human PC2/Polycystin-2 Nanodisc Protein
Catalog No: PC2-HP001
- Species
- Human
- Expression System
- HEK293
- Tag
- His
Product overview
Human PC2/Polycystin-2 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Human PC2/Polycystin-2 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Val968 (accession: Q13563-1).
Product Details
- Molecular Aliases
- Polycystin-2; Polycystin 2; PC2; Polycystwin; R48321; PKD2; TRPP2
- Protein Length
- Met1-Val968
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. Functions include receptor-operated, nonselective cation channel activity in the plasma membrane, intracellular Ca2+ release channel activity in the endoplasmic reticulum (ER), and mechanosensitive channel activity in the primary cilium of renal epithelial cells.
References
- (1) Peña-Oyarzun D, Batista-Gonzalez A, Kretschmar C, Burgos P, Lavandero S, Morselli E, Criollo A. New emerging roles of Polycystin-2 in the regulation of autophagy. Int Rev Cell Mol Biol. 2020;354:165-186. doi: 10.1016/bs.ircmb.2020.02.006. Epub 2020 Mar 11. PMID: 32475472.(2) Cantero MDR, Cantiello HF. Polycystin-2 (TRPP2): Ion channel properties and regulation. Gene. 2022 Jun 15;827:146313. doi: 10.1016/j.gene.2022.146313. Epub 2022 Mar 18. PMID: 35314260.
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