Biotinylated Human CCR6 Nanodisc Protein
Catalog No: CCR6-HB001
- Species
- Human
- Expression System
- HEK293
- Tag
- His
Product overview
Biotinylated Human CCR6 Nanodisc Protein is a full-length multi-pass membrane protein presented in a Nanodisc format for antibody discovery, binding assays and method development. Recombinant Biotinylated Human CCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus. It contains Met1-Met374 (accession: P51684).
Product Details
- Molecular Aliases
- C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; DRY6; DCR2; GPRCY4; LARC receptor; CD196; CKRL3 / CMKBR6; GPR29; STRL22; BN-1
- Protein Length
- Met1-Met374
- Expression System
- HEK293
- Endotoxin
- Less than 1 EU per μg by the LAL method.
- Buffer / Formulation
- Supplied as 0.22 μm filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
- State
- Liquid
- Storage Conditions
- Valid for 12 months from date of receipt when stored at -80°C. Aliquot where appropriate and minimize freeze-thaw cycles.
Background
The CC chemokine receptor 6 (CCR6), a G protein-coupled receptor (GPCR) is an important receptor that is involved in regulating several aspects of mucosal immunity, including the ability to mediate the recruitment of immature dendritic cells (DCs) and mature DCs, and professional antigen presenting cells (APCs) to the sites of epithelial inflammation. Further, CCR6 mediates the homing of both CD4(+) T (T-helper; Th) cells and DCs to the gut mucosal lymphoid tissue.
References
- Ito T, Carson WF 4th, Cavassani KA, Connett JM, Kunkel SL. CCR6 as a mediator of immunity in the lung and gut. Exp Cell Res. 2011 Mar 10;317(5):613-9. doi: 10.1016/j.yexcr.2010.12.018. PMID: 21376174; PMCID: PMC3063449.
Have questions about this product?
Our technical team can help with product selection, application questions and order support.